Police are treating a "major blaze" at Cheshire restaurant Panacea on Tuesday as suspicious.
The fire broke out at the Alderley Edge eaterie, which is popular with footballers and celebrities, at 2230 on Tuesday.
Cheshire Police said no one was injured but the force wanted to speak to two people who were seen to arrive in a car before the fire broke out, according to the BBC.
Police said the pair were seen walking towards the building and then left in the car.
Det Insp Robert Hassall said: "We are particularly keen to speak to anyone who was in the area at the time and saw a dark coloured BMW or Audi shortly before 22:30 GMT."
The restaurant is due to re-open as a branch of Piccolino when a refurbishment is completed.
Panacea has been hit by fire before, after it was devastated by a 2008 blaze just days after opening following a £3m refurbishment.